background From 2002-2004 128 firstepisode schizophrenic patients were assessed regarding their pathology, social functioning, dup, medication use and many other areas. They were recruited for a clinical trial (medication strategies in first onset schizophrenia mesifos) comparing two medication strategies (continuation versus discontinuation of antipsychotics after stable remission). Relapse rates were twice as high in the discontinuated patients, but general outcome did not differ. Discontinuated patients were more often medication-free and were lower in total medication consumption over a two-year period, as intended. In a new study the cohort was followed up six years after termination of the trial.
aim The aim of this study was to follow up the patients as one incidence cohort and to compare the course of illness of these patients with that of earlier cohorts, e.g. as to recovery and remission. Guidelines have been introduced in 2005 for the treatment of schizophrenia, which could affect course of illness.
method The original cohort was traced and asked to participate. The interviews comprised schedules about pathology (panss), social functioning (gsds), use of care, medication use, relapse, hospitalisations (Life Chart Schedule), substance use and remission and recovery Andreasen criteria). Data collection covered the entire six-year period.
results Out of the original 128 probands, 103 were interviewed; of 18 sufficient information was available to make reliable assessments about critical research measures. Data collection has just been completed. No final outcome data is available at this point. In this presentation outcome will be presented regarding medication use, relapse, course and remission and recovery. Outcome of the entire group of n = 121 will be compared to relevant earlier studies.
conclusion Preliminary analyses suggest a possibly more favourable course.