background/aims Certain temperamental and neuropsychological constructs might be valuable tools in the early identification of individuals at-risk of future substance use. We hypothesize that high-intensity pleasure and response- inhibition at age 10-12 predict early onset of cannabis use, and that there is an indirect link between these predictors and onset of cannabis use via disruptive behavior.

methods Objectives were studied in trails, a prospective cohort study of Dutch adolescents. Measures included parent-reported highintensity pleasure (Early Adolescent Temperament Questionnaire; eatq-r), response-inhibition, measured with the Set Shifting Task of the Amsterdam Neuropsychological Tasks (ant), and parent and self-reported disruptive behavior (Child Behavior Checklist/6-18 and Youth Self- Report) at age 10-12. Cannabis use was assessed at age 12-14 by means of self-reports. Analyses were carried out in Mplus.

preliminary results Cannabis onset at age 12-14 was predicted by high-intensity pleasure but not by response-inhibition at age 10-12. Besides a direct effect of high-intensitypleasure and disruptive behavior on onset of cannabis use in the second model, we found an indirect link from high-intensity pleasure to onset of cannabis use via disruptive behavior.

conclusions Our results indicate that disruptive behavior explains part of the prospective relationship between high-intensity pleasure and onset of cannabis use in adolescence.