Special issue

G. Dom, A. Schellekens, R. Oude Voshaar, W. van den Brink

Editorial

The impact of Dutch and Flemish scientists on the progress of addiction medicine

C.P. O'Brien

Review article

Impulse control in addiction: a translational perspective

L. Schmaal, N. Broos, L. Joos, T. Pattij, A.E. Goudriaan

Summary
background Impulsivity is a hallmark of addiction and predicts treatment response and relapse. Impulsivity is, however, a complex construct. Translational cross-species research is needed to give us greater insight into the neurobiology ...

Review article

Motivational processes in addiction: the role of craving, salience and attention

I.H.A. Franken, R.W. Wiers

Summary
background Motivational processes play an important role in addictive behaviours. Craving is mainly an explicit or conscious process that can motivate individuals to continue alcohol, take drugs or smoke cigarettes. Craving also plays a ro...

Review article

Neuromodulation as an intervention for addiction: overview and future prospects

J. Luigjes, R. Breteler, S. Vanneste, D. de Ridder

Summary
background In recent years several neuromodulation techniques have been introduced as interventions for addiction.
aim To review and discuss studies that have investigated the effects of treating addiction by means of electroencephalograph...

Dopamine and excessive alcohol consumption: how genes interact with their environment

A. Schellekens, R. Scholte, R. Engels, R.-J. Verkes

Summary
background Hereditary factors account for approximately 50% of the risk of developing alcohol dependence. Genes that affect the dopamine function in the brain have been extensively studied as candidate genes.
aim To present the results of...

Substance use disorders and ADHD: an overview of recent Dutch research

K. van Emmerik-van Oortmerssen, C.L. Crunelle, P.J. Carpentier

background adhd is an important risk factor for the development of substance use disorders (sud).
aim To provide an overview of recent Dutch research into the prevalence of adhd in sud populations and the neurobiological substrate of the reduced e...

Cannabis use and the risk of psychotic disorders. An update

R. Kuepper, R. van Winkel, C. Henquet

Summary
background The use of cannabis has been linked to an increased risk for psychosis, irrespective of confounding factors such as age, gender, use of other drugs and reverse causality. Over the last few years a great deal of research has bee...

Autism spectrum disorders and substance use disorders

B.B. Sizoo, P.J.M. van Wijngaarden-Cremers, R.J. van der Gaag

Summary
background So far, little is known about the comorbidity of substance use disorders (sud) and autism spectrum disorders (asd).
aim To increase our knowledge of sud in asd patients by means of a broad explorative study.
method In a cross-se...

Modafinil in alcohol-dependent patients: the effect on relapse

L. Joos, L. Schmaal, N. Broos, A.E. Goudriaan

Summary
background Relapse in alcohol dependence affects more than 50% of all alcohol-dependent patients. Diminished impulse control may perhaps provoke these high relapse rates and may therefore be a mechanism that can be targeted for treatment.
...

Detoxification of patients with GHB dependence

G.H. de Weert-van Oene, A.F.A. Schellekens, B.A.G. Dijkstra, R. Kamal, C.A.J. de Jong

Summary
background A new detoxification method for ghb dependence was developed recently in the Netherlands. The method involves the use of pharmaceutical ghb.
aim To describe the characteristics of ghb dependent inpatients, the course of the deto...

Pharmacogenetics in the treatment of tobacco addiction

M. Quaak, F.J. van Schooten, C.P. van Schayck

Summary
background Smokers vary in their genetic susceptibility to become addicted to smoking and probably also in their reaction to smoking cessation pharmacotherapies.
aim To provide an overview of the developments on the pharmacogenetics of the t...

Developments in pharmacotherapy: personalised pharmacotherapy?

G. Dom, W. van den Brink

Summary
background Effect-sizes of pharmacological treatments for addictive disorders are limited and a substantial number of patients do not derive any benefit from these treatments.
aim To develop strategies that will enhance the effectivity of ...

Psychological treatment in substance use disorders: focus for the future