Wetenschappelijk tijdschrift voor psychiaters, artsen in opleiding tot psychiater en andere geïnteresseerden
Case report
Clinical consequences due to interaction between olanzapine and fluvoxamine
summary Description of a patient with symptoms probably related to a high concentration of olanzapine. The clearance of olanzapine was decreased by inhibition of cytochrome p450-1a2 due to fluvoxamine. Measurement of cytochrome p450-1a2 activity during use of different dosages of olanzapine and fluvoxamine confirmed the inhibition.