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Tijdschrift voor Psychiatrie 63 (2021) 3, 209 - 214

Klinische Praktijk

Hyperprolactinemia and antipsychotics: it’s not always what it seems to be

A.E. Brandsma, R.H.A. van der Doelen, W.A. Ester

Hyperprolactinemia is a relatively frequent laboratory abnormality (30-80%) as a result of antipsychotics and a reason to reduce or stop them. We describe two youngsters with autism spectrum disorder whose hyperprolactinemia was based on a false-positive laboratory finding due to macroprolactin. The consequences were: unnecessary endocrinological evaluation including a brain MRI, and undesirable antipsychotic dose reduction. Thus, hyperprolactinemia can be due to a falsely elevated prolactin concentration. There should be an addition to the current guidelines in which a work-up for macroprolactin screening is included.