summary Schizophrenia can be characterised as a disorder with disinhibition of feeling of significance on the one hand, and diminished feeling of significance and intentionality on the other. These problems are associated with disturbances in the dopaminergic neurotransmission. Antipsychotics - dopamine antagonists - diminish disinhibited feeling of significance but can also attenuate desirable intentionality, feeling of significance and fun. Subjective experiences of patients can be reliable assessed. Subjective unwell-being is associated with a relatively high dopamine receptor occupancy by antipsychotic medication.