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Tijdschrift voor Psychiatrie 52 (2010) 5, 349 - 352

Case report

Diagnosis of epilepsy complicated by panic disorder and a non-specific reaction to a SSRI

A.J.B. Wanders, A.S. de Leeuw, H.J.G.M. van Megen

Differentiating panic disorder form epilepsy can be a difficult task. In this case study the task was made more complicated because the patient was being treated with the selective serotonin reuptake inhibitor (ssri) citalopram which evoked a partial response, thereby delaying the diagnosis of epilepsy. Research results demonstrate that ssris can have not only an antidepressive and calming effect, they can also have an anticonvulsant effect. However, there are also signs that, as this case illustrates, in the long term the anticonvulsant effect can actually convert to proconvulsant effect.