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Tijdschrift voor Psychiatrie 49 (2007) 8, 575 - 579

Case report

Clozapine and agranulocytosis: should treatment be continued?

J.P.A.M. Bogers

summary
This article describes four patients using clozapine, with neutropenia. Clozapine-induced neutropenia can be one of three types: pseudo, benign or malignant. The malignant type can give cause for serious concern; in that case treatment with clozapine must be stopped. Pseudo-neutropenia and benign neutropenia, however, occur frequently. In these cases it is probably unnecessary to stop clozapine medication, particularly if clozapine is clearly indicated.

keywords agranulocytosis, clozapine, neutropenia