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Tijdschrift voor Psychiatrie 39 (1997) 9, 706 - 711

Short report

Effect of genetic polymorphisms in cytochrome-P450 enzymes on metabolism of psychoactive drugs

J. van der Weide, L.S.W. Steijns, T. Kuipers

Numerous psychopharmacological compounds are eliminated mainly by the cytochrome- P450 (CYP) enzyme system. Activity of the CYP enzymes is determined by genetic factors. Nearly every individual can be classified by molecular genetic methods as either a poor or an extensive metabolizer. Routine genotyping should be performed in every patient prior to drug therapy. For some patients dosage adjustment or the use of drug alternatives is possible.