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Tijdschrift voor Psychiatrie 62 (2020) 9, 798 - 804

Klinische Praktijk

Alexander disease as an explanation for long-term unexplained psychiatric symptoms in a young girl

S.B.J. Oude ophuis, M.S. van der Knaap, P.F. Schothorst

Alexander disease is a rare genetic disorder, usually characterized by leukodystrophy, causing progressive degeneration of white matter in the central nervous system. We describe a case of a 7-year-old girl with long term medically unexplained symptoms and suspicion of a psychiatric disorder, who was diagnosed with Alexander disease. Building on this case, a literature search was conducted for psychiatric symptoms..

keywords Alexander disease, anxiety, depression, eating difficulties, leukodystrophy