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Tijdschrift voor Psychiatrie 61 (2019) 8, 544 - 553

Review article

The efficacy of baclofen in alcohol dependence

A. Neven, G.J.H. Dumont

background In the past years numerous studies have investigated the efficacy of baclofen for alcohol dependence. After publication of several reviews a number of new randomized controlled trials have been published. Two recent meta-analyses, based on largely the same studies, reported contrary results. One meta-analysis showed a positive effect on time to relapse and abstinence at endpoint. The other meta-analysis did not show an effect on the primary outcome measures.
aim To clarify the clinical relevance of the effect of baclofen on alcohol use in patients with a disorder in the use of alcohol, in the light of the positive and the negative meta-analysis.
method A systematic literature search using Medline, Embase and PsycINFO (Prisma guideline).
results We found 16 randomized controlled trials in which the effect of baclofen was studied. Seven of them showed a significant positive effect of baclofen on (one or more of the) primary outcome measures.

keywords baclofen, pharmacotherapy