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Tijdschrift voor Psychiatrie 60 (2018) 12, 827 - 833

Review article

The three-monthly paliperidone palmitate depot in the treatment of schizophrenia

S.K. Spoelstra, L. Bais, H. Knegtering

background A three-monthly formulation of intramuscular paliperidone palmitate has been available on the Dutch and Belgian markets since 2016.
aim To provide an overview of the indication, effectiveness and side-effects of this injectable three-monthly formulation of paliperidone and to offer considerations for clinical practice.
method A clinically-oriented literature study.
results Three-monthly paliperidone palmitate depot appears to be as effective as the monthly paliperidone depot and has the same profile of side-effects.
conclusion Three-monthly paliperidone palmitate is an effective treatment option for schizophrenia. However, future research and clinical practice need to clarify the position of this depot in the treatment trajectory.

keywords long-acting injectable antipsychotics, 3-monthly paliperidone palmitate, schizophrenia