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Tijdschrift voor Psychiatrie 42 (2000) 2, 121 - 125

Case report

Fever and leukocytosis as transient adverse effects of clozapine

J. Vink

A patient is described who after initiation of treatment with clozapine had twice a period of some days with fever, leukocytosis and elevated sedimentation rate. An infection or malignant neuroleptic syndrome could be excluded. The patient was eventually successfully treated with clozapine. Some literature concerning these adverse effects is discussed. It is important to differentiate between dangerous and transient non-dangerous adverse effects of clozapine, so that treatment is not stopped unnecessarily.

keywords clozapine, fever, leukocytosis, side-effects