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Tijdschrift voor Psychiatrie 43 (2001) 10, 715 - 720

Short report

The place of clozapine in the treatment of schizophrenia

P.F.J. Schulte

Even after the introduction of the new atypical antipsychotics clozapine as yet has an unequalled superior efficacy in refractory schizophrenia. Unfortunately, it has also some rare but dangerous side-effects. Nevertheless, the overall mortality in patients with schizophrenia decreases with treatment with clozapine. Patients who have been treated with a classical and a new atypical antipsychotic with only partial or no response should be offered a trial with clozapine.

keywords adverse effects, clozapine, refractory schizophrenia