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Tijdschrift voor Psychiatrie 38 (1996) 5

New research

The syndrome of Lujan-Fryns in the differential diagnosis of schizophrenia

D. Steemans, M. De Hert, J.P. Fryns, J. Peuskens

Schizophrenia is considered an heterogenous disorder. Different etiopathological mechanisms can attribute to a similar clinical picture as described in DSM-criteria. We present a case of a young man diagnosed on different occasions with DSM-III-R schizophrenia and mild mental retardation. Clinical examination revealed signs and symptoms most compatible the diagnosis of Lujan-Fryns syndrome, an X-linked mental retardation with `Marfanoid features' and frequently associated with psy- chotic or other psychiatric symptoms. In all patients with symptoms of schizophrenia and mental retardation the Lujan-Fryns syndrome should be considered in the differ- ential diagnosis.