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Tijdschrift voor Psychiatrie 41 (1999) 5, 287 - 291

Short report

Treatment of psychosis with low dose typical neuroleptics

L. de Haan, I. Maksmovic

An overview is given of studies on efficacy, side effects and d2 receptor occupancy of low versus high doses of typical neuroleptics. Doses between 2 and 7 mg haloperidol equivalent a day are as effective as higher doses on positive symptoms and are associated with less side effects and improvement of negative symptoms. Low doses of typical neuroleptics give d2-receptor occupancy in the putative therapeutic range.

keywords dose, d2-antagonist, psychosis