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Tijdschrift voor Psychiatrie 54 (2012) 8, 747 - 751

Case report

The Kleine-Levin syndrome and the treatment with methylphenidate

S.H.A. Brouns, J. Schieveld, C. Leue

Summary
A 17-year-old man was referred to the Med-Psych-Unit because of recurrent episodes of hypersomnia, megaphagia, hypersexual behaviour and cognitive disturbances. Over the period of three years he suffered more than 10 episodes of hypersomnia each lasting 8 to 16 days. The clinical presentation was suggestive of the Kleine-Levin syndrome. The symptoms disappeared after treatment with methylphenidate, but it was not clear whether this could be attributed to the medication or to the self-limiting character of the illness. The Kleine-Levin syndrome is often clinically not recognised due to the variation in the symptoms and the lack of objective diagnostic examination.

keywords episodic hypersomnia, Kleine-Levin syndrome, mood stabilisers, psychostimulants