Home

Tvp19 10 omslag kijk verder

Tijdschrift voor Psychiatrie 52 (2010) 10, 719 - 723

Case report

Sleep disturbances in Smith-Magenis syndrome: treatment with melatonin and beta-adrenergic antagonists

A. Van Thillo, K. Devriendt, D. Willekens

summary
Smith-Magenis syndrome is a generic disorder, characterised by physical, neurological and behavioural features and caused by a 17p11.2 deletion. Patients with this syndrome typically display an inversion of the sleep-wake cycle. In this article we describe clinical developments in a two-year-old girl with Smith-Magenis syndrome whose sleep problems were successfully treated with melatonin and beta-adrenergic blockers. We also mention relevant data obtained in our literature search.

keywords beta-adrenergic blockers, melatonin, sleep disturbances, Smith-Magenis syndrome