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Tijdschrift voor Psychiatrie 42 (2000) 5, 307 - 318

New research

Experience with a relapse program (cra) combined with naltrexon in the treatment of opioid-dependency: Effect on addiction behavior and the predictive value of psychiatric comorbidity

H.G. Roozen, A.J.F.M. Kerkhof, W. van den Brink

background There is an increasing interest in the agent naltrexon, an opiate-antagonist, in the treatment of opiate-addicts. Evidence suggests that the effects of this agent are the most favourable supposition when combined with a psychosocial intervention programme as in the Community Reinforcement Approach (cra).
aims This open study presents the results of a combined naltrexon/cra treatment (n = 24) and consists of a pre-post measurement.
methods An open (n = 24) consisting of a pre-post measurement.
results After a period of six months 58% (14/24) did not relapse, after one year at least 55% (12/22) still met the initial goal of abstinence. A comparison was made between the abstinence group and those clients relapsing into frequent opioid use. The differences found were significant in the cluster b-score of personality disorders and in polydrug users. Nevertheless the results of these subgroups were unexpectantly good. Compared to a methadon population (n = 20), the intervention population was representative in several different areas including addiction, demographic, legal, psychopathology and specific personality disorders.
conclusion The combination of naltrexon/intensive cra in an outpatient setting appears to be promising.

keywords Community Reinforcement Approach (cra), naltrexone, opioids, prevention of relapse