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Tijdschrift voor Psychiatrie 49 (2007) 5, 327 - 331

Short report

Psychopathology in female carriers of the fragile X mutation

S. Hageman, F. Van Den Eede, F. Vandendriessche, S. Claes

summary   Fragile X syndrome is, after Down's syndrome, the most common form of mental retardation. Women are potential carriers and can have the defective gene on one of their two X chromosomes without developing the complete syndrome. In this paper we examine which psychiatric disturbances may appear or develop in women because they are carriers of the fragile X mutation. Carriers have been found to have a higher frequency of anxiety disorders, affective disorders and schizotypal features.

keywords fragile X syndrome, heterozygote, symptoms