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Tijdschrift voor Psychiatrie 47 (2005) 6, 391 - 393

Case report

A psychotic relapse, provoked by aripiprazole. A case study

Y. de Kok

A case is described of a man suffering from schizophrenia, who was doing well on risperidone but who became acutely psychotic when risperidone was replaced by aripiprazole. The probable explanation is that risperidone created a hypodopaminergic state with increased sensitivity of the dopamine receptors and as a result aripiprazole may have acted primarily as a dopamine agonist.

keywords adverse effects, aripiprazole, dopamine antagonists, psychotic disorder