Tijdschrift voor Psychiatrie 44 (2002) 10, 703 - 707
Case report
Clinical consequences due to interaction between olanzapine and fluvoxamine
summary Description of a patient with symptoms probably related to a high concentration of olanzapine. The clearance of olanzapine was decreased by inhibition of cytochrome p450-1a2 due to fluvoxamine. Measurement of cytochrome p450-1a2 activity during use of different dosages of olanzapine and fluvoxamine confirmed the inhibition.
keywords cytochrome-p450, fluvoxamine, interaction, olanzapine