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Tijdschrift voor Psychiatrie 44 (2002) 10, 703 - 707

Case report

Clinical consequences due to interaction between olanzapine and fluvoxamine

J.P. de Jong, B. Hoogenboom, L. Doude van Troostwijk, L. de Haan

summary Description of a patient with symptoms probably related to a high concentration of olanzapine. The clearance of olanzapine was decreased by inhibition of cytochrome p450-1a2 due to fluvoxamine. Measurement of cytochrome p450-1a2 activity during use of different dosages of olanzapine and fluvoxamine confirmed the inhibition.

keywords cytochrome-p450, fluvoxamine, interaction, olanzapine